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. 2013 Feb 27;8(2):e56719. doi: 10.1371/journal.pone.0056719

Figure 2. Cox6a2 −/− mice are protected against high-fat diet-induced obesity.

Figure 2

(A) Mice were fed a regular diet or a HFD starting from 6 weeks of age (n = 5 for WT, n = 14–16 for Cox6a2 −/− mice). Body weight was monitored weekly. The right panel shows representative images of WT and Cox6a2 −/− mice after 12 weeks of HFD feeding, (B) Absolute food intake, relative food intake and feed efficiency of mice fed a HFD (n = 5), (C) Average weight of gastrocnemius muscle, heart, liver, subcutaneous WAT and gonadal WAT dissected from mice that were fed a HFD for 12 weeks (n = 5). (D) Representative pictures of H&E staining of gonadal WAT of mice fed a HFD for 12 weeks. (E) Quantification of subcutaneous and gonadal WAT cell size and density (n = 5). *p<0.05, **p<0.01, ***p<0.001. In all panels, data represent mean+SEM.