Table 2. On-study and change from baseline plasma lipoprotein subfraction concentrations (95% confidence interval) by treatment assignment.

Adjustment	Placebo	Simvastatin & Niacin	Antioxidant vitamins	Simvastatin, Niacin & Antioxidant vitamins	Anova significance for group differences
LDL-peak
On study	25.82	26.40	25.48	26.04
	(25.57, 26.08)	(26.15, 26.65)	(25.25, 25.71)	(25.81, 26.27)
		P = 0.002	P = 0.06	P = 0.21	P = 7.2×10−6
Change	0.29	0.66	−0.03	0.36
	(0.05, 0.53)	(0.42, 0.90)	(−0.25, 0.19)	(0.14, 0.58)
		P = 0.04	P = 0.05	P = 0.69	P = 0.0008
LDL-I
On study	0.48	0.40	0.40	0.35
	(0.41, 0.54)	(0.34, 0.46)	(0.34, 0.46)	(0.29, 0.41)
		P = 0.09	P = 0.08	P = 0.005	P = 0.04
Change	0.03	−0.10	0.04	−0.09
	(−0.05, 0.12)	(−0.18, −0.02)	(−0.04, 0.11)	(−0.17, −0.01)
		P = 0.03	P = 0.98	P = 0.03	P = 0.02
LDL-IIa
On study	0.52	0.45	0.41	0.34
	(0.44, 0.60)	(0.37, 0.53)	(0.34, 0.49)	(0.27, 0.42)
		P = 0.19	P = 0.05	P = 0.001	P = 0.01
Change	0.06	−0.09	0.05	−0.13
	(−0.04, 0.15)	(−0.19, 0.00)	(−0.04, 0.14)	(−0.21, −0.04)
		P = 0.03	P = 0.89	P = 0.008	P = 0.009
LDL-IIb
On study	0.78	0.52	0.69	0.51
	(0.67, 0.88)	(0.41, 0.62)	(0.59, 0.79)	(0.41, 0.61)
		P = 0.0009	P = 0.25	P = 0.0004	P = 0.0005
Change	0.05	−0.22	0.05	−0.20
	(−0.07, 0.16)	(−0.33, −0.11)	(−0.05, 0.15)	(−0.30, −0.10)
		P = 0.001	P = 0.98	P = 0.002	P = 0.0001
LDL-IIIa
On study	0.52	0.28	0.72	0.38
	(0.42, 0.62)	(0.19, 0.38)	(0.62, 0.81)	(0.29, 0.47)
		P = 0.001	P = 0.006	P = 0.04	P = 1.2×10−8
Change	−0.05	−0.29	0.09	−0.21
	(−0.16, 0.05)	(−0.39, −0.19)	(−0.01, 0.19)	(−0.30, −0.11)
		P = 0.002	P = 0.06	P = 0.04	P = 2.0×10−5
LDL-IIIb
On study	0.16	0.08	0.19	0.10
	(0.12, 0.19)	(0.05, 0.12)	(0.15, 0.22)	(0.06, 0.13)
		P = 0.006	P = 0.23	P = 0.02	P = 0.0001
Change	−0.03	−0.05	0.03	−0.05
	(−0.07, 0.01)	(−0.09, −0.01)	(0.00, 0.07)	(−0.09, −0.02)
		P = 0.44	P = 0.03	P = 0.34	P = 0.006
LDL-IVa
On study	0.13	0.10	0.13	0.11
	(0.11, 0.14)	(0.08, 0.11)	(0.12, 0.15)	(0.09, 0.12)
		P = 0.01	P = 0.78	P = 0.05	P = 0.007
Change	0.01	−0.03	0.02	−0.01
	(−0.02, 0.03)	(−0.05, 0.00)	(0.00, 0.04)	(−0.03, 0.01)
		P = 0.05	P = 0.42	P = 0.31	P = 0.03
LDL-IVb
On study	0.12	0.10	0.12	0.11
	(0.11, 0.13)	(0.08, 0.11)	(0.11, 0.13)	(0.10, 0.12)
		P = 0.007	P = 0.99	P = 0.34	P = 0.02
Change	0.01	−0.01	0.02	0.00
	(0.00, 0.03)	(−0.03, 0.00)	(0.00, 0.03)	(−0.02, 0.02)
		P = 0.02	P = 0.80	P = 0.29	P = 0.05
LDL-C
On study	2.99	1.92	2.95	2.04
	(2.80, 3.18)	(1.73, 2.11)	(2.78, 3.13)	(1.87, 2.21)
		P = 3.3×10−15	P = 0.77	P = 3.9×10−13	P<10−15
Change	−0.29	−1.46	−0.10	−1.17
	(−0.49, −0.10)	(−1.65, −1.27)	(−0.29, 0.08)	(−1.34, −0.99)
		P<10−15	P = 0.17	P = 1.6×10−9	P<10−15
HDL-C
On study	0.89	1.03	0.85	0.93
	(0.84, 0.94)	(0.98, 1.08)	(0.81, 0.90)	(0.88, 0.98)
		P = 0.0003	P = 0.35	P = 0.28	P = 0.0001
Change	0.07	0.22	0.03	0.15
	(0.03, 0.11)	(0.18, 0.26)	(−0.01, 0.06)	(0.11, 0.18)
		P = 2.9×10−7	P = 0.13	P = 0.005	P = 4.9×10−10
Triglycerides
On study	2.13	1.40	2.73	1.85
	(1.67, 2.59)	(0.95, 1.85)	(2.30, 3.15)	(1.43, 2.26)
		P = 0.03	P = 0.06	P = 0.37	P = 0.0005
Change	−0.09	−0.87	0.34	−0.82
	(−0.48, 0.30)	(−1.25, −0.49)	(−0.01, 0.70)	(−1.17, −0.47)
		P = 0.006	P = 0.11	P = 0.007	P = 4.9×10−6