Table 4. Odds ratio (95% confidence interval) for primary disease endpoints (coronary-related deaths, myocardial infarctions, stroke, revascularization for worsening ischemia) per a one standard deviation increment in on-study LDL-peak diameter and LDL-subclass concentrations.
Additional adjustments | No additional adjustment | Additional adjustment for: | |
Group | Group and lipids | ||
LDL-peak | 0.70 | 0.84 | 0.87 |
(0.41, 1.19) | (0.47, 1.47) | (0.43, 1.79) | |
P = 0.19 | P = 0.53 | P = 0.71 | |
LDL-I | 0.85 | 0.80 | 0.85 |
(0.49, 1.46) | (0.45, 1.42) | (0.42, 1.75) | |
P = 0.55 | P = 0.44 | P = 0.67 | |
LDL-IIa | 0.76 | 0.76 | 0.84 |
(0.44, 1.32) | (0.43, 1.35) | (0.41, 1.71) | |
P = 0.33 | P = 0.35 | P = 0.63 | |
LDL-IIb | 0.83 | 0.73 | 0.81 |
(0.49, 1.43) | (0.42, 1.27) | (0.42, 1.57) | |
P = 0.51 | P = 0.27 | P = 0.54 | |
LDL-IIIa | 1.36 | 1.08 | 1.25 |
(0.84, 2.22) | (0.63, 1.84) | (0.70, 2.24) | |
P = 0.21 | P = 0.79 | P = 0.45 | |
LDL-IIIb | 1.73 | 1.56 | 1.77 |
(1.12, 2.69) | (0.98, 2.47) | (1.07, 2.93) | |
P = 0.01 | P = 0.06 | P = 0.03 | |
LDL-IVa | 1.18 | 1.05 | 1.08 |
(0.74, 1.87) | (0.64, 1.71) | (0.64, 1.83) | |
P = 0.48 | P = 0.86 | P = 0.76 | |
LDL-IVb | 1.13 | 0.96 | 1.03 |
(0.67, 1.91) | (0.54, 1.74) | (0.55, 1.90) | |
P = 0.66 | P = 0.90 | P = 0.94 |
Logistic regression analyses adjusted for baseline age, sex, BMI, current smoking status. Effects are per standard deviation increase in the on-study LDL-peak diameter (8.050 nm), LDL-I (0.185 mmol/L), LDL-IIa (0.234 mmol/L), LDL-IIb (0.326 mmol/L), LDL-IIIa (0.328 mmol/L), LDL-IIIb (0.113 mmol/L), LDL-IVa (0.049 mmol/L), and LDL-IVb (0.039 mmol/L).