Table 2. Associations between artificially-sweetened non-carbonated soft drinks consumption during pregnancy and child asthma in the Danish National Birth Cohort.

Frequencyof intake		Cases/N	Asthma (18 months)	P for trend**	Cases/N	Asthma (7years - ISAAC)	P for trend**	Cases/N	Ever asthma (DNPR)	P for trend**	Cases/N	Ever asthma (RMPS)	P for trend**
			N = 44,650			N = 38,165			N = 38,272			N = 38,272
			OR (95% CI)			OR (95% CI)			OR (95% CI)			OR (95% CI)
Never	Crude	4,632/29,392	1.00 (ref.)	<0.0001	1,018/25,508	1.00 (ref.)	0.20	1,443/25,584	1.00 (ref.)	0.001	7,78725,586	1.00 (ref.)	<0.0001
	Adjusted*			<0.0001			0.84			0.08			0.001
<1 serv/week	Crude	606/3,258	1.22 (1.11, 1.34)		97/2,685	0.90 (0.73, 1.12)		172/2,692	1.14 (0.97, 1.34)		851/2,690	1.06 (0.97, 1.15)
	Adjusted*		1.22 (1.09, 1.36)			0.98 (0.76, 1.27)			1.20 (0.98, 1.48)			1.06 (0.95, 1.18)
Weekly	Crude	1,179/6,137	1.27 (1.18, 1.36)		216/5,087	1.07 (0.92, 1.24)		326/5,102	1.14 (1.01, 1.29)		1,750/5,102	1.19 (1.12, 1.27)
	Adjusted*		1.21 (1.11, 1.31)			0.94 (0.77, 1.14)			1.13 (0.97, 1.33)			1.07 (0.99, 1.16)
> = 1 serv/day	Crude	1,202/5,863	1.38 (1.28, 1.48)		210/4,885	1.08 (0.93, 1.26)		333/4,894	1.22 (1.08, 1.38)		1,765/4,894	1.29 (1.21, 1.38)
	Adjusted*		1.23 (1.13, 1.33)			1.00 (0.82, 1.22)			1.14 (0.98, 1.34)			1.15 (1.06, 1.25)

^*Adjusted for maternal age, smoking, parity, prepregnancy BMI, physical activity, breastfeeding, socioeconomic position, child sex, maternal history of asthma, maternal history of allergies, paternal history of asthma, paternal history of allergies, and energy (in quintiles).

^**Median values (0, 0.5, 3.5, and 7) for each intake group entered as a continuous variable into the model.

ISAAC: International Study of Asthma and Allergies in Childhood.

DNPR: Danish National Patient Registry.

RMPS: Register of Medicinal Products Statistics.