Table 3. Associations between artificially-sweetened carbonated soft drink consumption during pregnancy and child asthma in the Danish National Birth Cohort.

Frequency of intake		Cases/N	Asthma (18 months)	P for trend**	Cases/N	Asthma (7 years - ISAAC)	P for trend**	Cases/N	Ever asthma (DNPR)	P for trend**	Cases/N	Ever asthma (RMPS)	P for trend**
			N = 44,638			N = 38,149			N = 38,258			N = N = 38,258
			OR (95% CI)			OR (95% CI)			OR (95% CI)			OR (95% CI)
Never	Crude	4,942/29,896	1.00 (ref.)	<0.0001	1,018/25,661	1.00 (ref.)	0.09	1,509/25,733	1.00 (ref.)	0.04	7,944/25,731	1.00 (ref.)	<0.0001
	Adjusted*			0.14			0.27			0.19			0.01
<1 serv/week	Crude	1,013/5,620	1.11 (1.03, 1.20)		185/4,856	0.96 (0.82, 1.13)		287/4,866	1.01 (0.88, 1.15)		1,606/4,868	1.10 (1.03, 1.18)
	Adjusted*		1.17 (1.07, 1.27)			0.91 (0.74, 1.12)			1.01 (0.85, 1.19)			1.11 (1.02, 1.20)
Weekly	Crude	1,327/7,399	1.10 (1.03, 1.18)		267/6,189	1.09 (0.95, 1.25)		351/6,212	0.96 (0.85, 1.08)		2,092/6,211	1.14 (1.07, 1.21)
	Adjusted*		1.06 (0.98, 1.15)			1.04 (0.87, 1.23)			0.98 (0.84, 1.14)			1.10 (1.02, 1.19)
> = 1 serv/day	Crude	346/1,723	1.27 (1.12, 1.43)		66/1,443	1.16 (0.90, 1.50)		118/1,447	1.43 (1.17, 1.73)		511/1,448	1.22 (1.09, 1.36)
	Adjusted*		1.10 (0.95, 1.27)			1.18 (0.87, 1.59)			1.30 (1.01, 1.66)			1.13 (0.98, 1.29)

^*Adjusted for maternal age, smoking, parity, prepregnancy BMI, physical activity, breastfeeding, socioeconomic position, child sex, maternal history of asthma, maternal history of allergies, paternal history of asthma, paternal history of allergies, and energy (in quintiles).

^**Median values (0, 0.5, 3.5, and 7) for each intake group entered as a continuous variable into the model.

ISAAC: International Study of Asthma and Allergies in Childhood.

DNPR: Danish National Patient Registry.

RMPS: Register of Medicinal Products Statistics.