Figure 3. Amyloid plaques were detected with in vivo µMRI after intravenous femoral injection of USPIO-PEG-Aβ1-42.

In vivo T2*-weighted μMRI images show a 14 month-old APP/PS1 Tg mouse. B shows a higher magnification of the area in the red box of shown in A. C shows the matching tissue section to A immunolabeled with anti-Aβ 4G8/6E10. D shows a higher magnification of the area in the red box of C. Arrowhead highlight some of the matching dark spots seen by μMRI with the immunolabeled tissue sections.