Table 2. T2* Measurements.

Mouse Groups	Left Cortex	Right Cortex	Left Hippocampus	Right Hippocampus	Cerebellum
APP/PS1 Tg from Set 1	38.63±1.35	38.62±0.97	39.84±0.54	39.88±0.61	43.5±2.19
APP/PS1 Tg from Set 2	40.2±1.5	40.26±1.69	42.44±2.98	42.07±2.8	43.14±2.16
APP/PS1 Tg from set 3	44.6±1.08	42.32±1.58	44.57±2.5	45.22±2.64	44.97±2.51
Wild-type from set 1	42.2±0.99	41.97±1.02	42.2±0.99	43.23±1.47	43.5±3.65
p-values of Tg from set 1 compared to Tg from set 2	0.02156	0.01095	0.007489	0.01558	0.71402
p-values of Tg from set 1 compared to Tg from set 3	<0.00001	<0.00001	<0.00001	<0.00001	0.92865
p-values of Tg compared to WT from set 1	<0.00001	<0.00001	<0.00001	<0.00001	0.99863

Shows a comparison of the absolute T2* values in the different mouse groups and the p-values comparing different groups using a two-tailed Students t-test. This data indicates that sufficient USPIO-PEG-Aβ1-42 is able to cross the BBB in vivo and result in T2* changes in USPIO-PEG-Aβ1-42 injected APP/PS1 mice, which can be attributed to specific binding to Aβ plaques, given the significantly lower T2* measurements in areas of the brain affected with Aβ deposition (cortex and hippocampus).