TABLE 1.
Liver Tumor Occurrence and Injury
| PARAMETERS | WILD TYPE | KNOCKOUT | ||
|---|---|---|---|---|
|
| ||||
| Male | Female | Male | Female | |
|
| ||||
| Number of mice | 25 | 29 | 22 | 23 |
| Number of mice with tumor | 0 | 0 | 1 | 8 |
| Mouse age (month) | 9–17 | 9–17 | 9 | 9–17 |
| ALT±SD (U/L) | 20±3.5 | 19±2.1 | 76±70.2* | 113±105.6* |
| ALT±SD (U/L) in mice with tumor | 234 | 174±114.1** | ||
p<0.05;
p<0.01 compared to wild type of same sex.