Skip to main content
. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: J Mol Med (Berl). 2013 Jan 18;91(3):311–321. doi: 10.1007/s00109-013-0993-5

Figure 3. Ocular sections from mouse models of ocular neovascularization (NV).

Figure 3

(A) A normal mouse retina histochemically stained with a lectin that selectively stains vascular cells and counter-stained to show other retinal cells illustrates the 3 capillary beds of the retina with some penetrating vessels showing connections or part of connections between the beds.

(B) A retina from a mouse with oxygen-induced ischemic retinopathy shows dilation of the vessels within the retina with NV on the surface of the retina (arrows).

(C) A retina from a rho/VEGF transgenic mouse, a model of retinal angiomatous proliferation, shows a vessel extending from the deep capillary bed of the retina through the photoreceptors into the subretinal space.

(D) A retina from a mouse with choroidal NV after laser-induced rupture of Bruch’s membrane. The arrow shows a vessel extending from the choroid through the rupture in Bruch’s membrane into the subretinal space where it connects to a large convoluted network of new vessels, many of which are cut in cross section to show their lumens (astericks). The superior margin of the choroidal NV that borders the photoreceptors is shown by the arrowheads.