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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: J Nutr Biochem. 2012 Jul 26;24(5):770–775. doi: 10.1016/j.jnutbio.2012.04.007

Fig. 6.

Fig. 6

PFKFB3/iPFK2 regulation of systemic insulin sensitivity. Male PFKFB3+/− mice and wild-type littermates, at 5–6 weeks of age, were fed an HFD for 12 weeks and treated with rosiglitazone (Rosi, 10 mg/kg/day in PBS) or vehicle (PBS) orally for the last 4 weeks of the feeding regimen. At the end of feeding/treatment regimen, blood samples were collected and used to measure plasma levels of glucose and insulin. HOMA-IR was calculated using the following equation: HOMA-IR=basal glucose (mmol/L)×basal insulin (mU/L)/22.5. Data are means±S.E.; n=4–6. **P<.01, rosiglitazone vs. vehicle for the same genotype; †P<.05 and ††P<.01, PFKFB3+/− vs. wild type for the same treatment (rosiglitazone or vehicle).