Figure 3.

The changes in MBP, TPR, CO, and HR in WKYs and SHRs during tyramine-induced norepinephrine release after pre-treatment with the centrally active, non-selective α₂AR-agonist clonidine and the peripherally restricted α₂AR antagonist L-659,066, separately or combined. After curve evaluation using Repeated Measures Analyses of Variance and Covariance (please see Materials and Methods), significant responses (* within symbol) and group differences (* in brackets) were detected at 3 and 15 min for ΔMBP and ΔTPR, and at 15 min for ΔCO and ΔHR, as indicated. Baselines prior to tyramine are shown in Table 1. * within symbols and * in brackets: P ≤ 0.025 for ΔMBP and ΔTPR, and P ≤ 0.05 for ΔCO and ΔHR.