Table 2.

Summary of global miRNA-deficient (Dicer1^-/- and DGCR8^-/-) or over-expression (Eri1^-/-) NK cells.

	Sullivan et al. (2012)	Bezman et al. (2010)	Thomas et al. (2012)
Cre model	hCD2-Cre	ER-Cre	Global knockout
Gene	Dicerfl/fl	Dicerfl/fl/DGCR8fl/fl	Eril-/-
Effect on miRNAs	↓	↓	↑
Survival	↓	↓	~
Proliferation	↓	↓	↓
# NK cells	↓*	↓*	↓*
IFN-γ production	↑	↓!	↓!
CD107a	↑	↓	~
Receptor repertoire alterations	None observed	↓NKG2D	Multiple, especially ↓Ly49H/D
MCMV response	↑IFN-γ production	~IFN-γ production ↓Ly49H+ NK cells	~IFN-γ production ↓Ly49H+ NK cells
In vitro cytotoxicity	N/A	N/A	~

^*In particular, at latest stages of NK cell maturation.

^!In response to activating (ITAM) receptor-mediated stimulation.