Table 2.
Sullivan et al. (2012) | Bezman et al. (2010) | Thomas et al. (2012) | |
---|---|---|---|
Cre model | hCD2-Cre | ER-Cre | Global knockout |
Gene | Dicerfl/fl | Dicerfl/fl/DGCR8fl/fl | Eril-/- |
Effect on miRNAs | ↓ | ↓ | ↑ |
Survival | ↓ | ↓ | ~ |
Proliferation | ↓ | ↓ | ↓ |
# NK cells | ↓* | ↓* | ↓* |
IFN-γ production | ↑ | ↓! | ↓! |
CD107a | ↑ | ↓ | ~ |
Receptor repertoire alterations | None observed | ↓NKG2D | Multiple, especially ↓Ly49H/D |
MCMV response | ↑IFN-γ production | ~IFN-γ production ↓Ly49H+ NK cells | ~IFN-γ production ↓Ly49H+ NK cells |
In vitro cytotoxicity | N/A | N/A | ~ |
In particular, at latest stages of NK cell maturation.
In response to activating (ITAM) receptor-mediated stimulation.