Fig. (1).

Neuroendocrine control of energy homeostasis (details in text).

1. afferent system generates signals released from adipose tissue (leptin), pancreas (insulin) and stomach(ghrelin)
2. central processing unit present in hypothalamus having two set of neurons: orexigenic and anorexigenic neurons
3. efferent system carries out anabolic and catabolic signals by modulating feeding behavior or energy expenditure

NPY/AgRP= Neuropeptide Y/ Agouti related peptide; POMC/CART= Pro-opiomelanocortin/ Cocaine and Amphetamine Related Transcript; NPY Rec= Neuropeptide receptor; MCH= Melanin Concentrating Hormone; α MSH= α Melanocyte Stimulating Hormone; Mc4R= Melanocortin receptor; TRH= Thyrotrophin Releasing Hormone; CRH= Corticotrophic Releasing Hormone