Table 2.
Cell Origin of iPS Cells
| Cell Source | Vector | Reprogramming Factors |
|---|---|---|
| MEF [1] | Retrovirus | Mouse Oct3/4, Sox2, Klf4, and c-Myc |
| Mouse adult bone marrow mononuclear cells [11] | Retrovirus | Mouse Oct3/4, Sox2, Klf4, and c-Myc |
| Mouse B lymphocytes [12] | Retrovirus | Mouse Oct3/4, Sox2, Klf4, and c-Myc |
| Mouse skeletal myoblasts [14] | Retrovirus | Mouse Oct3/4, Sox2, Klf4, and c-Myc |
| Mouse tail tip fibroblasts and skin fibroblasts [4] | Retrovirus | Oct3/4, Sox2,and Klf4 |
| Mouse neural stem cells [19] | Retrovirus | Oct4 together with either Klf4 or c-Myc |
| Mouse liver and stomach cells [15] | Retrovirus | Oct3/4, Sox2, Klf4, c-Myc |
| Mouse fibroblast and hepatocyte [16] | Adenovirus | Oct3/4, Sox2, Klf4, c-Myc |
| Mouse pancreatic islet beta cells [34] | Lentivirus | Oct3/4, Sox2, Klf4, and c-Myc |
| Mouse hair follicles: [20] | Retrovirus | Mouse Oct4 |
| Mouse and human fibroblast [23] | Retrovirus | Oct3/4, Sox2, Klf4, and Glis1 |
| Mouse or human ADS cells [35] | Retrovirus | mouse Oct3/4, Sox2, Klf4, and c-Myc |
| Mouse and human amniocytes [36] | Retrovirus | Human=Oct4, Sox2,Klf4, c-Myc, mouse= Klf4, c-Myc |
| Human ADS [17, 21, 37] | Retrovirus Nonviral minicircle |
Mouse Oct4, Sox2, Klf4, and L-Myc Oct4, Sox2, Nanog and LIN28 |
| Human CD34+ blood cells [13,38] | Retrovirus | Oct3/4, Sox2, Klf4, and c-Myc |
| Human CD34+ cord blood cells [39] | Retrovirus | Oct4, Sox2, Klf4, and c-Myc |
| Human dental tissue cells [40] | Retrovirus | Oct4, Sox2, Klf4, c-Myc or Lin28,Nanog, Oct4, Sox2 |
| Human skin fibroblast [2] | Retrovirus | human Oct3/4, Sox2, Klf4, and c-Myc |
| Human somatic cells [3] | Lentivirus | Oct4, Sox2, Nanog, and LIN28 |
| HUVEC [41] | Retrovirus | Oct3/4, Sox2, Klf4, and c-Myc |
| Human oral mucosa fibroblasts [42] | Retrovirus | Oct3/4, Sox2, Klf4, and c-Myc |
ADS= Adipose-derived stem cells
HUVEC= human umbilical vein endothelial cells