TABLE 1.
Patient Characteristics
| Familial (N = 38) | Sporadic (N = 37) | P-value | |
|---|---|---|---|
| Age at diagnosis (years) | 51 (41-76) | 56 (36-71) | 0.03 |
| Sex | |||
| Female | 17 (45%) | 12 (32%) | 0.35 |
| Male | 21 | 25 | |
| Rai Stage at Sampling | |||
| Low (0) | 6 | 8 | 0.77 |
| Intermediate (1-2) | 19 | 15 | |
| High (3-4) | 11 | 9 | |
| Time from diagnosis to Sample (months) | 61 (25-99) | 39 (15-64) | 0.004 |
| Time from diagnosis to Therapy (months) | 51 (30-94) | 50 (17-74) | 0.13 |
| Previously Treated at Sampling | 8 (21%) | 5 (14%) | 0.26 |
| Untreated at Sampling | 30 (79%) | 32 (86%) | |
| Treated Since Sampling | 9 | 15 | |
| IGHV Mutational Status | |||
| Unmutated | 14 (37%) | 21 (57%) | 0.24 |
| Mutated, <98% | 20 (53%) | 16 (43%) | |
| ZAP-70 Expression | |||
| Positive (>20%) | 14 (37%) | 16 (43%) | 1.0 |
| Negative (20% or less) | 18 | 20 | |
| CD38 Expression | |||
| Positive (30% or more) | 11 (29%) | 11 (30%) | 1.0 |
| Negative (less than 30%) | 24 | 25 | |
| Interphase FISH (n= 56) | |||
| Del 17p | 6 | 8 | |
| Del 11q | 2 | 10 | |
| Trisomy 12 | 5 | 4 | |
| Normal | 7 | 5 | |
| Del 13q | 10 | 15 | |
| Homozygous del 13q | 8 | 2 | |
| Multiple | 9 | 12 |
FISH, fluorescent in situ hybridization