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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: J Pediatr Surg. 2013 Jan;48(1):47–55. doi: 10.1016/j.jpedsurg.2012.10.043

Fig 3.

Fig 3

Rapamycin Decreases Osteoclastogenesis in a Mouse Neuroblastoma Xenograft. (A) Treatment with rapamycin (5 mg/kg) daily for 3 weeks decreased the number of osteoclasts in mouse femurs by 2-fold (*p=0.022) and 1.6-fold in CHLA-20 and NB1691 (**p=0.003) xenografts respectively as detected by TRAP staining, indicating a decrease in RANKL signaling in treated mice through an upregulation of OPG. (B) Example of TRAP stained control and treated mouse femurs. Treated femurs demonstrate a significant decrease in osteoclasts by TRAP staining compared to controls.