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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: J Pediatr Surg. 2013 Jan;48(1):47–55. doi: 10.1016/j.jpedsurg.2012.10.043

Fig 4.

Fig 4

Rapamycin Increased Bone Volume Fraction and Cortical Thickness in Treated Mice. (A) Bone volume fractions (BVF) in CHLA-20 (*p=0.042) and NB1691 (**p=0.001) xenografts increased as a result of rapamycin treatment indicating an inhibition of osteoclastogenesis by the neuroblastoma xenografts. (B) Cortical thickness in CHLA-20 (*p=0.031) and NB1691 (**p=0.017) xenografts was also increased relative to control, similarly indicating decreased osteoclastogenesis by neuroblastoma xenografts. (C) Representative μCT Images of control and treated mouse femurs. Control femurs demonstrate obvious cortical breakdown by tumor, while treated femurs demonstrate a preservation of cortical architecture after two weeks.