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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Gastroenterology. 2012 Jul 13;143(3):708–18.e1-5. doi: 10.1053/j.gastro.2012.05.053

Figure 5.

Figure 5

TLR4 in the intestinal epithelium is required for the development of NEC. Terminal ileum from newborn mice and evaluated by H&E after (Ai, v, and vii) breastfeeding or (Aii–iv, vi, viii) induction of NEC in either TLR4 or TRIF-deficient strains. (B, C, and E) RT-PCR in intestinal mucosa of wild-type (red bars or white bars), TLR4−/− (green bars), TLR4ΔIEC (blue bars), and TRIF−/− (black bars) for (B) inducible nitric oxide synthase or (C and E) IL-6 as shown. (D and F) Severity of NEC. Mean ± SEM; **P < .05 versus wild-type (WT) NEC; *P <.05 versus WT control. Representative of >100 fields, >10 mice/group. Bar = 100 µm.