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. 2012 Feb 15;16(4):363–373. doi: 10.1089/ars.2010.3874

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Copyright 2012, Mary Ann Liebert, Inc.

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FIG. 5. — COX-2 derived prostaglandin F_2α (PGF_2α) mediates endothelial dysfunction in renal arteries of RHRs. Acetylcholine (100 μM)-stimulated release of PGF_2α (A), 8-isoprostane (B), and 6-keto PGF_1α (prostacyclin [PGI₂]) (C) in control rats, RHRs, and RHRs treated with celecoxib or tempol. Contractions induced by PGF_2α (D), 8-isoprostane (E), and PGI₂ (F) in renal arteries of RHRs and control rats. (G) Effects of celecoxib and SC-560 on H₂O₂ (100 μM)-stimulated released of PGF_2α in renal arteries. (H) Plasma concentration of PGF_2α in control rats, RHRs, and RHRs treated with celecoxib or tempol. (I) Effects of celecoxib and S18886 on PGF_2α-induced reduction of EDRs in renal arteries from control rats. Results are mean±SEM of four to eight experiments. *p<0.05 versus control (SD), ^#p<0.05 versus RHR.