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. 2013 Apr 10;18(11):1263–1272. doi: 10.1089/ars.2011.4430

FIG. 2.

FIG. 2.

TMX deficiency does not cause severe ER dysfunction. (A) Liver extracts from wild-type (+/+) and TMX−/− mice were analyzed by immunoblotting with antibodies specific for calnexin (CNX), BiP, TUB, PDI, and ERp57. (B) Surface expression patterns of disulfide-bonded membrane proteins. Spleen cells were stained with the indicated antibodies and analyzed by flow cytometry. Wild-type (WT), shaded; TMX−/−, thick lines; unstained cells (NC), dotted lines. BiP, binding protein; ER, endoplasmic reticulum; PDI, protein disulfide isomerase.