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Upregulation of p53-target genes in LPS/GalN-treated TMX−/− mice. (A, B) Induction of S100A8, annexin A1, p21/Waf1, Bax, and Gadd45γ was verified by real-time quantitative PCR performed in triplicate. mRNA expression levels were normalized to that of 18S ribosomal RNA. The graphs show the fold changes for each gene compared with the untreated wild-type mice. Data are the mean values±SD of two animals.
