FIG. 8.

Loss of TMX enhances liver damage associated with oxidative stress. (A–D) Increased lipid peroxidation in LPS/GalN-treated TMX^−/− mice. Representative images of HNE staining in liver sections from wild-type (+/+) or TMX^−/− mice treated with vehicle (A, B) or LPS/GalN (24 h postinjection (C, D). Bars represent 100 μm. (E) Loss of TMX enhances liver damage induced by TAA. Serum levels of AST and ALT were measured 24 h after TAA injection. Data represent the mean values±SD of four animals. *p<0.05 (Student's t-test). HNE, 4-hydroxy-2-nonenal; TAA, thioacetamide.