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The MID and Piwi Domains Are Highly Sensitive to Mutations.
(A) Structural overview highlighting the density of missense mutations on or in close proximity to the MID-Piwi interface. A close-up view of the region shows the location of the 13 missense mutations in this region.
(B) Presentation of mutations directly involved in the 5′RNA binding. Conserved residues are part of a H-bond network involved in 5′phosphate coordination.
