Figure 7.

PSK in combination with docetaxel enhances NK cell activity of splenocytes from TRAMP-C2 tumor bearing mice. Splenocytes from mice treated with saline control or PSK and docetaxel alone and in combination were isolated and cultured in vitro with YAC-1 murine tumor target cells and assessed for NK cell killing of YAC-1 cells. Splenic cells from animals treated with PSK and docetaxel combination therapy had the highest level of NK cell activity at all effector:target ratios. NK cell activity induced by DTX/PSK was significantly enhanced at the 50:1 E:T ratio (p=0.045 using a linear mixed model to analyze data from 17 mice).