Table 1.
Age adjusted characteristics of Johns Hopkins Hospital prostatectomy cohort by statin use at prostatectomy from 1993 to 2006
| No Statin | Statin | p Value (Wald test) | |
|---|---|---|---|
| Characteristics | |||
| No. pts (%) | 2,012 (83.9) | 386 (16.1) | |
| Mean age | 56.0 | 57.7 | <0.0001 |
| % Race: | |||
| White | 92.4 | 93.0 | 0.58 |
| Black | 3.0 | 1.4 | |
| Asian | 0.7 | 0.9 | |
| Other/missing | 3.9 | 4.6 | |
| Mean BMI (kg/m2) | 26.3 | 26.7 | 0.06 |
| Mean ht (inches) | 70.6 | 70.6 | 0.48 |
| % Cigarette smoking: | |||
| Never | 33.4 | 34.0 | 0.28 |
| Current | 1.5 | 1.0 | |
| Former | 27.5 | 31.5 | |
| Missing | 37.5 | 33.6 | |
| % Prostate Ca family history | 23.4 | 28.2 | 0.06 |
| % Aspirin use | 7.5 | 19.5 | <0.0001 |
| % ACE inhibitor use | 7.3 | 15.7 | <0.0001 |
| Mean days biopsy-surgery | 112 | 112 | 0.87 |
| Mean surgery yr | 1998 | 2000 | <0.0001 |
| Mean yrs from surgery to recurrence* | 4.1 | 4.0 | 0.44 |
| Preop | |||
| % Stage: | |||
| T1a–T1b | 0.7 | 0.7 | |
| T1c | 67.0 | 73.0 | |
| T2a–T2c | 31.5 | 25.4 | |
| T3a | 0.6 | 0.9 | 0.02 |
| % Gleason sum: | |||
| 6 or Less | 81.9 | 80.0 | |
| 7 (less than 4+3) | 12.1 | 13.1 | |
| 7 (4 or greater + 3) | 5.8 | 6.6 | 0.72 |
| Mean PSA (ng/ml) | 7.1 | 6.3 | 0.004 |
| No. PSA tests | 2.4 | 2.6 | 0.07 |
| Mean PSA velocity (ng/ml/yr) | 1.4 | 1.4 | 0.53 |
| Postop | |||
| % Stage: | |||
| Organ confined | 77.9 | 83.3 | |
| Extraprostatic extension | 16.4 | 12.8 | |
| Seminal vesicle invasion or worse | 4.0 | 2.3 | 0.04 |
| % Gleason sum: | |||
| 6 or Less | 68.1 | 70.5 | |
| Less than 7 (4 + 3) | 21.4 | 20.5 | |
| 7 or Greater (4 + 3) | 10.3 | 9.0 | 0.67 |
| % Pos surgical margins | 8.1 | 6.1 | 0.11 |
| Mean PSA doubling time (mos) | 12.8 | 12.4 | 0.28 |
*
In 247 men with recurrence.