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. 2011 Dec 15;40(4):1058–1065. doi: 10.3892/ijo.2011.1299

Figure 1.

Figure 1

Effects of gomisins A and N on TRAIL-induced cell death. (A) HeLa cells were pretreated with 100 μM gomisin A or gomisin N for 30 min, followed by treatment with TRAIL (100 ng/ml) for 3 h. Cell lysates were collected and subjected to Western blot analysis to detect the cleavage of caspase-3 and PARP-1. (B) HeLa cells were treated with the indicated dosed of gomisin N for 30 min, followed by TRAIL treatment for 24 h. Cell viability was determined by WST-1 assay. Data are presented as the mean ± SD of twelve independent experiments; **P<0.01 vs. control group; ##P<0.01 vs. combined treatment group with 100 μM gomisin N and TRAIL.