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. 2011 Dec 6;40(4):983–994. doi: 10.3892/ijo.2011.1283

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Copyright © 2012, Spandidos Publications

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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Heatmap of the methylation alterations detected by the MS-AFLP arrays. Only alterations detected in two or more of the UC samples are included in the figure. Red indicates hypermethylation (log2 ratio < −1) and blue indicates hypomethylation (log2 ratio > 1). Every column corresponds to a different sample, and every row corresponds to a different MS-AFLP array spot. Cases and spots were clustered according to the Euclidean distance using MeV. The analysis revealed 5 main spot clusters (A–E). Samples were classified in three main groups based on the methylation status of the clusters A, B and D. For more information about the genes in each cluster, see the main text.