Table III.
Clinicopathological features | No. of casesb | HOXA5 expression | HOXD10 expression | HOXD11 expression | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Higher | Lower | P-value | Higher | Lower | P-value | Higher | Lower | P-value | ||
Age | ||||||||||
40–60 years | 25 | 11 | 15 | 0.26 | 14 | 11 | 0.70 | 13 | 12 | 1.00 |
>60 years | 9 | 6 | 3 | 4 | 5 | 5 | 4 | |||
Tumor location | ||||||||||
Tongue | 12 | 6 | 7 | 1.00 | 5 | 7 | 0.47 | 6 | 6 | 0.72 |
Floor of mouth | 22 | 11 | 11 | 13 | 9 | 13 | 9 | |||
pT classification | ||||||||||
T1 | 3 | 3 | 1 | 1.00 | 2 | 1 | 0.73 | 2 | 1 | 1.00 |
T2 | 11 | 4 | 7 | 6 | 5 | 4 | 7 | |||
T3 | 13 | 6 | 7 | 7 | 6 | 11 | 2 | |||
T4 | 7 | 4 | 3 | 3 | 4 | 2 | 5 | |||
pN classification | ||||||||||
N+ | 14 | 7 | 8 | 1.00 | 8 | 6 | 0.73 | 6 | 8 | 1.00 |
N0 | 20 | 10 | 10 | 10 | 10 | 13 | 7 | |||
Pathological grade | ||||||||||
Well differentiated | 16 | 9 | 8 | 0.73 | 8 | 8 | 1.00 | 6 | 10 | 0.08 |
Moderately differentiated | 18 | 8 | 10 | 10 | 8 | 13 | 5 | |||
Lymphatic invasion (LI)a | ||||||||||
LI− | 21 | 11 | 11 | 0.72 | 12 | 9 | 0.73 | 12 | 9 | 1.00 |
LI+ | 12 | 5 | 7 | 6 | 6 | 7 | ||||
Perineural invasion (PI) | ||||||||||
PI− | 16 | 7 | 9 | 0.73 | 10 | 6 | 0.32 | 9 | 7 | 1.00 |
PI+ | 18 | 10 | 9 | 8 | 10 | 10 | 8 | |||
Local recurrence | ||||||||||
Present | 6 | 4 | 3 | 0.68 | 2 | 4 | 0.38 | 2 | 4 | 0.36 |
Absent | 28 | 13 | 16 | 16 | 12 | 17 | 11 |
Missing data of one patient.
The number of paired cases with detectable expression by qRT-PCR was 35 OSCC samples for HOXA5 and 34 OSCC samples for HOXD10 and HOXD11 transcripts.