Table III.

Association of HOXA5, HOXD10 and HOXD11 homeobox genes expression levels with OSCC clinicopathological features (P-value according to Fisher's exact test).

Clinicopathological features	No. of casesb	HOXA5 expression			HOXD10 expression			HOXD11 expression
		Higher	Lower	P-value	Higher	Lower	P-value	Higher	Lower	P-value
Age
40–60 years	25	11	15	0.26	14	11	0.70	13	12	1.00
>60 years	9	6	3		4	5		5	4
Tumor location
Tongue	12	6	7	1.00	5	7	0.47	6	6	0.72
Floor of mouth	22	11	11		13	9		13	9
pT classification
T1	3	3	1	1.00	2	1	0.73	2	1	1.00
T2	11	4	7		6	5		4	7
T3	13	6	7		7	6		11	2
T4	7	4	3		3	4		2	5
pN classification
N+	14	7	8	1.00	8	6	0.73	6	8	1.00
N0	20	10	10		10	10		13	7
Pathological grade
Well differentiated	16	9	8	0.73	8	8	1.00	6	10	0.08
Moderately differentiated	18	8	10		10	8		13	5
Lymphatic invasion (LI)a
LI−	21	11	11	0.72	12	9	0.73	12	9	1.00
LI+	12	5	7		6	6		7
Perineural invasion (PI)
PI−	16	7	9	0.73	10	6	0.32	9	7	1.00
PI+	18	10	9		8	10		10	8
Local recurrence
Present	6	4	3	0.68	2	4	0.38	2	4	0.36
Absent	28	13	16		16	12		17	11

^aMissing data of one patient.

^bThe number of paired cases with detectable expression by qRT-PCR was 35 OSCC samples for HOXA5 and 34 OSCC samples for HOXD10 and HOXD11 transcripts.