Table 3.
Effect of % solids concentration and % ethanol concentration on the aerosolization characteristics of AS in spray dried combination particles (values are mean (SD), n ≥ 3).
| Experiment | AS content (%) | ED (%) | MMAD (μm) | FPF5μm/ED (%) | FPF1μm/ED (%) |
|---|---|---|---|---|---|
| Effect of % Solid Concentration | |||||
| 4 (1 %) | 27.9 (0.6) | 76.9 (0.2)# | 1.8 (0.0)# | 94.4 (0.5)# | 14.5 (1.7)# |
| 5 (0.2 %) | 27.4 (0.2) | 84.2 (0.6)# | 1.9 (0.3)# | 81.4 (7.4)# | 17.2 (6.0)# |
| 6 (0.5 %) | 27.3 (0.9)⧧ | 81.4 (2.0)# | 1.4 (0.1)# | 95.3 (1.1)# | 28.3 (3.1)# |
| Effect of % Ethanol Concentration | |||||
| 6 (20 %) | 27.3 (0.9)⧧ | 81.4 (2.0) | 1.4 (0.1)*** | 95.3 (1.1) | 28.3 (3.1)*** |
| 7 (0 %) | 27.6 (0.1) | 79.0 (0.7) | 1.7 (0.2)*** | 92.4 (4.5) | 17.6 (2.8)*** |
⧧
Values were average of 6 different batches.
Statistically significant effects on process variables were:
#
% solid concentration; ED, MMAD, FPF5μm/ED and FPF1μm/ED (Expt 4, Expt 5 and Expt 6): one-way ANOVA: P<0.05
***
Ethanol amount; FPF1μm/ED (Expt 6 vs Expt 7): t-test: P < 0.05