Table I. Altered expression of redox genes encoded by nuclear and mitochondria DNA.

The gene functional groups were categorized according to GoMinor (Gene Ontology). All the numbers are the folds of changes relative to the untreated cells. Genes involved in mitochondrial function was significantly enriched in both cell lines (HCT116 wt-p53: p = 0.04, HCT116 p53-null: p = 0.0001). MT; mitochondria, MTCO1; Homo sapiens cytochrome c oxidase I (MTCO1), mRNA; MTCO2; H. sapiens cytochrome c oxidase II (MTCO2), mRNA; MTATP6; H. sapiens ATP synthase 6 (MTATP6), mRNA; MTATP8; H. sapiens ATP synthase 8 (MTATP8), mRNA; MTND3, H. sapiens NADH dehydrogenase 3 (MTND3), mRNA; MTND4, H. sapiens NADH dehydrogenase 4 (MTND4), mRNA; MTND6; H. sapiens NADH dehydrogenase 6 (MTND6), mRNA; MTND4L; H. sapiens NADH dehydrogenase 4L (MTND4L), mRNA; WEE1; Wee1 + (S. pombe) homolog/protein x 013; SDHB, succinate dehydrogenase subunit B; UQCRH, ubiquinol-cytochrome c reductase hinge protein; COX8, cytochrome c oxidase subunit VIII; SFN, h. sapiens stratifin (SFN), mRNA; FDXR, ferredoxin reductase; DUT, DUTP pyrophosphatase.

Gene description	Accession number	Source	HCT116 wt-p53			HCT116 p53-null
			5-FU	DENSPM	5-FU + DENSPM	5-FU	DENSPM	5-FU + DENSPM
MTCO1	NM_173704	MT	1.48	1.25	0.78	0.90	0.75	0.27
MTCO2	NM_173705	MT	1.56	0.89	0.66	1.16	0.58	0.14
MTATP6	NM_173702	MT	1.49	0.81	0.66	0.95	0.64	0.23
MTATP8	NM_173703	MT	1.49	0.76	0.64	0.89	0.54	0.21
MTND3	NM_173710	MT	0.87	0.62	0.62	0.68	0.29	0.19
MTND4	NM_173711	MT	1.44	0.82	0.63	0.63	0.47	0.15
MTND6	NM_173714	MT	0.75	0.46	0.65	0.55	0.76	0.54
MTND4L	NM_173712	MT	1.34	0.74	0.63	0.62	0.36	0.14
WEE1	XM_049184	Nuclear	0.49	0.68	0.31	0.68	0.84	0.90
SDHB	NM_003000	Nuclear	1.07	0.75	1.52	1.07	1.24	1.62
UQCRH	NM_006004	Nuclear	0.95	1.16	1.15	1.15	1.33	1.67
COX8	NM_004074	Nuclear	1.25	1.29	1.57	1.12	1.12	1.69
SFN	NM_006142	Nuclear	1.66	1.89	3.03	1.17	0.85	1.20
FDXR	XM_056248	Nuclear	2.00	2.60	2.36	1.18	1.06	1.20
DUT	U31930	Nuclear	0.89	0.76	0.50	0.94	1.48	1.38