Table 2.

Relation of alcohol intake and alcohol metabolism genotype to breast cancer incidence

Daily alcohol intake or alcohol metabolism genotype	Controls N, %	Cases N, %	Minimally adjusted hazard ratio (95%CL)*	Fully adjusted hazard ratio (95% CL)**
Daily servings of alcohol
None (n, %)	202, 18.9	146, 14.0	1.00	1.00
>0–0.99 (n, %)	604, 56.5	604, 58.0	1.34 (1.04, 1.73)	1.31 (1.01, 1.71)
1.00–1.99 (n, %)	80, 7.5	99, 9.5	1.64 (1.12, 2.39)	1.54 (1.04, 2.28)
2.00–2.99 (n, %)	32, 3.0	43, 4.1	1.77 (1.05, 2.97)	1.75 (1.02, 3.00)
3.00+ (n, %)	25, 2.3	35, 3.4	2.01 (1.14, 3.53)	2.00 (1.11, 3.61)
Alcohol servings/day (quintile)
0–<0.001	202, 18.9	146, 14.0	1.00	1.00
0.001–<0.032	262, 24.5	243, 23.3	1.28 (0.96, 1.71)	1.27 (0.94, 1.71)
0.032–<0.111	200, 18.7	217, 20.9	1.41 (1.05, 1.90)	1.38 (1.01, 1.89)
0.111–<0.672	172, 16.1	176, 16.9	1.35 (0.99, 1.85)	1.31 (0.95, 1.82)
0.672+	107, 10.0	145, 13.9	1.82 (1.30, 2.56)	1.74 (1.22, 2.47)
ADH1B genotype
GG	960, 89.7	917, 88.1	1.00	1.00
GA	80, 7.5	91, 8.7	1.41 (1.00, 1.99)	1.31 (0.91, 1.87)
AA	26, 2.4	26, 2.5	1.46 (0.58, 3.67)	1.58 (0.59, 4.23)
GA or AA	106, 9.9	117, 11.2	1.41 (1.00, 1.99)	1.31 (0.92, 1.88)
ADH1C genotype
GG	164, 15.3	173, 16.6	1.05 (0.81, 1.37)	1.04 (0.79, 1.37)
GA	465, 43.5	427, 41.0	0.87 (0.71, 1.06)	0.86 (0.70, 1.05)
AA	423, 39.5	425, 40.8	1.00	1.00
CYP2E1 genotype
CC	974, 91.0	957, 91.9	1.00	1.00
CT	70, 6.5	64, 6.2	0.88 (0.59, 1.31)	0.81 (0.54, 1.23)
TT	4, 0.4	7, 0.7	1.91 (0.57, 6.39)	1.70 (0.49, 5.94)
CT or TT	74, 6.9	71, 6.8	0.95 (0.66, 1.37)	0.87 (0.60, 1.28)

^*adjusted for age at baseline, year of baseline, race and ethnicity

^**adjusted for age at baseline, year of baseline, race and ethnicity, age at menarche, age at menopause, parity, age at first live birth, family history of breast cancer, personal history of benign breast disease