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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Breast Cancer Res Treat. 2012 Feb 14;133(2):785–792. doi: 10.1007/s10549-012-1972-1

Table 3.

Relation of alcohol intake to breast cancer incidence, stratified by genotype

Gene Genotype Average daily alcohol
intake (drinks per day)		 Minimally adjusted
OR (95%CL)* 		Fully adjusted
OR (95% CL)**
ADH1B GG None (n, %)
>0–0.99 (n, %)
1.00–1.99 (n, %)
2.00–2.99 (n, %)
3.00+ (n, %)		 1.00
1.34 (1.02, 1.76)
1.80 (1.20, 2.68)
1.91 (1.12, 3.28)
2.25 (1.25, 4.05)		 1.00
1.29 (0.97, 1.72)
1.66 (1.09, 2.52)
1.88 (1.07, 3.29)
2.22 (1.19, 4.13)
GA or AA None (n, %)
>0–0.99 (n, %)
1.00–1.99 (n, %)
2.00–2.99 (n, %)
3.00+ (n, %)		 1.00
0.95 (0.39, 2.30)
0.53 (0.12, 2.45)
0.24, 0.02, 3.58)
0.00		 1.00
0.90 (0.33, 2.46)
0.51 (0.06, 4.55)
0.30 (0.01, 8.77)
0.00
ADH1C GG None (n, %)
>0–0.99 (n, %)
1.00–1.99 (n, %)
2.00–2.99 (n, %)
3.00+ (n, %)		 1.00
1.71 (0.92, 3.19)
1.29 (0.49, 3.39)
1.24 (0.33, 4.63)
2.11 (0.33, 4.63)		 1.00
1.68 (0.81, 3.49)
1.11 (0.36, 3.41)
1.69 (0.42, 6.75)
2.14 (0.31, 14.91)
GA None (n, %)
>0–0.99 (n, %)
1.00–1.99 (n, %)
2.00–2.99 (n, %)
3.00+ (n, %)		 1.00
0.99 (0.66, 1.47)
1.50 (0.86, 2.64)
1.85 (0.77, 4.46)
1.06 (0.47, 2.39)		 1.00
1.03 (0.66, 1.58)
1.29 (0.71, 2.36)
1.59 (0.61, 4.14)
1.01 (0.43, 2.41)
AA None (n, %)
>0–0.99 (n, %)
1.00–1.99 (n, %)
2.00–2.99 (n, %)
3.00+ (n, %)		 1.00
1.57 (1.05, 2.36)
1.69 (0.87, 3.28)
1.72 (0.78, 3.79)
5.31 (1.76, 16.01)		 1.00
1.59 (1.03, 2.46)
1.80 (0.87, 3.72)
1.87 (0.80, 4.36)
4.13 (1.19, 14.26)
CYP2E1 CC None (n, %)
>0–0.99 (n, %)
1.00–1.99 (n, %)
2.00–2.99 (n, %)
3.00+ (n, %)		 1.00
1.32 (1.01, 1.71)
1.77 (1.19, 2.63)
1.61 (0.93, 2.79)
1.96 (1.09, 3.54)		 1.00
1.29 (0.98, 1.70)
1.70 (1.13, 2.57)
1.61 (0.91, 2.85)
1.96 (1.06, 3.65)
CT or TT None (n, %)
>0–0.99 (n, %)
1.00–1.99 (n, %)
2.00–2.99 (n, %)
3.00+ (n, %)		 1.00
1.25 (0.43, 3.59)
0.34 (0.06, 1.90)
3.20 (0.50, 20.36)
0.56 (0.03, 10.36)		 1.00
0.86 (0.20, 3.74)
0.05 (0, 0.95)
5.28 (0.64, 43.41)
0.46 (0.01, 15.71)
*

adjusted for age at baseline, year of baseline, race and ethnicity

**

adjusted for age at baseline, year of baseline, race and ethnicity, age at menarche, age at menopause, parity, age at first live birth, family history of breast cancer, personal history of benign breast disease