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. Author manuscript; available in PMC: 2013 Feb 28.
Published in final edited form as: N Engl J Med. 2003 Jul 17;349(3):247–257. doi: 10.1056/NEJMoa022289

Figure 1. Kaplan–Meier Estimates of Overall Survival among Patients with Stage II or Stage III Colon Cancer According to the Microsatellite-Instability Status of the Tumor.

Figure 1

In the absence of adjuvant chemotherapy, the patients with tumors displaying high-frequency microsatellite instability had significantly longer overall survival than patients with tumors exhibiting microsatellite stability or low-frequency microsatellite instability (hazard ratio for death, 0.31 [95 percent confidence interval, 0.14 to 0.72]; P=0.004)(Panel A). When the analysis was limited to the group receiving adjuvant chemotherapy, patients with tumors exhibiting high-frequency microsatellite instability did not have a significant increase in overall survival as compared with patients with tumors exhibiting microsatellite stability or low-frequency microsatellite instability (hazard ratio for death, 1.07 [95 percent confidence interval, 0.62 to 1.86]; P=0.80)(Panel B). The analysis included data for eight years from the date of randomization.