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. Author manuscript; available in PMC: 2013 Feb 28.
Published in final edited form as: Adv Exp Med Biol. 2012;740:603–638. doi: 10.1007/978-94-007-2888-2_27

Figure 3. Examples and illustrative effects of Type-I and Type-II α7-PAMs.

Figure 3

A) NS-1738, 5-HI, Invermectin and Genistein represent the family of Type-I α7-PAMs. Schematic current traces illustrate the effects of Type-I α7-PAMs on α7 nAChRs: Type-I α7-PAMs increase the peak of α7 nAChR-mediated responses but do not alter the rate of desensitization of α7 nAChRs. B) PNU-120596, TQS, A867744, JNJ-1930942 represent the family of Type-II α7-PAMs. Schematic current traces illustrate the effects of Type-II α7-PAMs on α7 nAChRs: Type-II α7-PAMs increase the peak of α7 nAChR-mediated responses and considerably reduce the desensitization of α7 nAChRs.