Table 2.
Associations Between Alcohol Intake Level and Incident Colorectal Cancer, Overall and by Anatomic Subsite
| ANY CRC (N = 1255) | PROXIMAL CRC (N = 633) | DISTAL CRC (N = 594) | |||||
|---|---|---|---|---|---|---|---|
| Alcohol Intake Levela | Person-Years | Events, N | RR (95% CI)b | Events, N | RR (95% CI)b | Events, N | RR (95% CI)b |
| Non-Consumers | 319,014 | 721 | 1.00 (ref.) | 360 | 1.00 (ref.) | 344 | 1.00 (ref.) |
| Consumers | |||||||
| Median Splitc, g/d | |||||||
| ≤3.4 | 125073 | 266 | 1.00 (0.86–1.15) | 137 | 1.05 (0.85–1.28) | 120 | 0.92 (0.74–1.14) |
| >3.4 | 120602 | 268 | 1.06 (0.91–1.24) | 136 | 1.08 (0.87–1.34) | 130 | 1.07 (0.86–1.33) |
| p trend | 0.50 | 0.47 | 0.74 | ||||
| Threshold Valued, g/d | |||||||
| ≤30 | 228085 | 492 | 1.03 (0.91–1.16) | 250 | 1.06 (0.89–1.25) | 231 | 0.99 (0.83–1.18) |
| >30 | 17590 | 42 | 1.00 (0.71–1.40) | 23 | 1.12 (0.71–1.77) | 19 | 0.89 (0.54–1.5) |
| p trend | 0.73 | 0.47 | 0.78 | ||||
| Quartiles, g/d | |||||||
| Q1 (x≤1.8) | 77855 | 172 | 1.04 (0.88–1.24) | 83 | 1.02 (0.80–1.31) | 84 | 1.04 (0.81–1.33) |
| Q2 (1.8<x≤3.4) | 47218 | 94 | 0.92 (0.74–1.15) | 54 | 1.08 (0.81–1.46) | 36 | 0.71 (0.50–1.02) |
| Q3 (3.4<x≤11) | 62605 | 139 | 1.10 (0.91–1.33) | 67 | 1.07 (0.82–1.41) | 70 | 1.14 (0.87–1.49) |
| Q4 (11<x) | 57997 | 129 | 1.02 (0.83–1.25) | 69 | 1.08 (0.82–1.44) | 60 | 0.98 (0.73–1.33) |
| p trend | 0.66 | 0.46 | 1.00 | ||||
a
as reported during the IWHS baseline evaluation (1986);
b
adjusted for age, BMI, WHR, smoking status, exogenous estrogen use, physical activity level, and daily intakes of total energy, total fat, sucrose, red meat, calcium, folate, methionine and vitamin E (mg/d);
c
median split among IWHS subjects who reported any alcohol consumption;
d
according to WHO/AICR report.(5)