Table 2.

Univariate Repeated Measures Associations of Baseline and Annual Measures with Odds of a Major Depressive Episode from Baseline Through Visit 9

	OR	95% CI	p-value
Baseline characteristics
Age	1.10	(1.03, 1.17)	0.005
African American	1.62	(0.76, 3.46)	0.21
History of major depressive disorder	4.51	(2.20, 9.25)	<.0001
Annual measures
Menopausal status (referent category: premenopause)
Perimenopause	2.17	(1.23, 3.81)	0.007
Postmenopause	3.43	(1.79, 6.56)	<.0001
Hormone therapy use	1.20	(0.38, 3.73)	0.76
Vasomotor symptoms ≥6days/past 2 weeks (hot flashes or night sweats)	2.50	(1.48, 4.22)	0.001
BMI	1.08	(1.02, 1.13)	0.004
Log E2**	0.82	(0.63, 1.06)	0.13
Log T**	1.04	(0.62, 1.74)	0.90
Log FSH**	1.25	(.97, 1.62)	0.08
Change in E2 from baseline*	1.00	(1.00, 1.00)	0.57
Change in Testosterone from baseline*	1.01	(1.00, 1.03)	0.10
Change in FSH from baseline*	1.00	(0.99, 1.01)	0.90

^*Adjusted for baseline value

^**Note: The results for hormones were similar when adjusted for BMI.