Table 1.
Average disorder content for each relation type from non-metabolic pathways (relations with less than 10 observations were excluded). First, the total number of unique nodes (All nodes) and their average disorder content are presented. Relations with significantly greater or less disorder are determined by Fisher’s exact test with Holm–Bonferroni correction for multiple testing. A notation of “>” means that nodes (N) or proteins (P) annotated with a given relation are significantly more disordered than nodes/proteins without that relation, and likewise “<” refers to relations with less disorder. Nodes of directed relations are subsequently classified as “from” (A) only, “to” (B) only, or both, with counts and average fraction disorder provided for each of the following categories. Relations with significantly greater or less disorder in nodes A over B are indicated in the last column, computed by the Wilcoxon signed rank test with p-value < 0.01
| Relation | All nodes
|
“From” and “to” nodes
|
||||||
|---|---|---|---|---|---|---|---|---|
| # Nodes | DO | Significance | # A | # B | DO A | DO B | Significance | |
| GErel, repression | 17 | 0.438 | 10 | 7 | 0.460 | 0.405 | ||
| PPrel, phosphorylation | 376 | 0.377 | >N, <P | 116 | 191 | 0.282 | 0.466 | A < B |
| PPrel, expression | 28 | 0.359 | 12 | 15 | 0.511 | 0.209 | A > B | |
| GErel, expression | 255 | 0.350 | >N, >P | 58 | 179 | 0.536 | 0.261 | A > B |
| PPrel, binding_association | 646 | 0.342 | >N, >P | 199 | 258 | 0.330 | 0.314 | |
| PPrel, dissociation | 52 | 0.340 | 22 | 20 | 0.367 | 0.359 | ||
| PPrel, inhibition | 429 | 0.320 | <P | 188 | 178 | 0.310 | 0.323 | |
| PCrel, binding_association | 170 | 0.318 | 43 | 77 | 0.289 | 0.289 | ||
| PPrel, dephosphorylation | 78 | 0.317 | 30 | 47 | 0.303 | 0.318 | ||
| PPrel, missing_interaction | 58 | 0.312 | 28 | 19 | 0.323 | 0.265 | ||
| PPrel, indirect_effect | 283 | 0.302 | 127 | 109 | 0.296 | 0.320 | ||
| PCrel, phosphorylation | 12 | 0.301 | 7 | 5 | 0.275 | 0.336 | ||
| PPrel, ubiquination | 52 | 0.298 | 22 | 30 | 0.280 | 0.312 | ||
| PPrel, activation | 1245 | 0.287 | <P | 428 | 458 | 0.278 | 0.292 | |
| GErel, indirect_effect | 21 | 0.282 | 6 | 15 | 0.216 | 0.309 | ||
| ECrel, activation | 20 | 0.278 | 7 | 8 | 0.242 | 0.275 | ||
| PCrel, indirect_effect | 23 | 0.278 | 3 | 20 | 0.100 | 0.304 | ||
| PCrel, inhibition | 26 | 0.272 | 11 | 15 | 0.206 | 0.320 | ||
| ECrel, compound | 46 | 0.270 | 11 | 15 | 0.234 | 0.312 | ||
| PPrel, compound | 83 | 0.246 | 28 | 41 | 0.246 | 0.239 | ||
| PCrel, activation | 139 | 0.233 | <N, <P | 31 | 81 | 0.208 | 0.262 | |