Table 1. GSEA pathway annotation.
| Gene set name | Genes in gene set | Genes in overlap | P-value |
|---|---|---|---|
| REACTOME SIGNALING BY EGFR | 48 | 4 | 1.59E-05 |
| ST_MYOCYTE_AD_PATHWAY | 23 | 3 | 5.09E-05 |
| KEGG_LONG_TERM_DEPRESSION | 70 | 4 | 7.12E-05 |
| KEGG_LONG_TERM_POTENTATION | 70 | 4 | 7.12E-05 |
| VERRECCHIA_DELAYED_RESPONSE_TO_TGFB1 | 36 | 3 | 1.99E-04 |
| ST_B_CELL_ANTIGEN_RECEPTOR | 39 | 3 | 2.53E-04 |
| KEGG_BLADDER_CANCER | 42 | 3 | 3.16E-04 |
| BENPORATH_SUZ12_TARGETS | 1037 | 11 | 3.82E-04 |
| NAKAMURA_METASTASIS | 47 | 3 | 4.42E-04 |
| VERRECCHIA_RESPONSE_TO_TGFB1_C4 | 11 | 2 | 5.30E-04 |
| KEGG_ENDOMETRIAL_CANCER | 52 | 3 | 5.95E-04 |
| REACTOME_SHC_MEDIATED_SIGNALING | 12 | 2 | 6.34E-04 |
| KEGG_NON_SMALL_CELL_LUNG_CANCER | 54 | 3 | 6.65E-04 |
| KEGG_NEUROTROPHIN_SIGNALING_PATHWAY | 126 | 4 | 6.81E-04 |
| KEGG_AXON_GUIDANCE | 129 | 4 | 7.44E-04 |
| REACTOME_GRB2_EVENTS_IN_EGFR_SIGNALING | 13 | 2 | 7.48E-04 |
| REACTOME_SOS_MEDIATED_SIGNALING | 13 | 2 | 7.48E-04 |
| KEGG_TIGHT_JUNCTION | 134 | 4 | 8.57E-04 |
| AMIT_EGF_RESPONSE_20_MCF10A | 14 | 2 | 8.71E-04 |
| REACTOME_SHC_RELATED_EVENTS | 14 | 2 | 8.71E-04 |
Abbreviation: GSEA, gene set enrichment analysis. Twenty most significant gene sets; 79 genes, mutated in at least 1 of the 5 primary MM (Figure 1) were annotated to pathways, using the c2 collection of the GSEA annotation database. Red label: growth factor receptor signaling pathways, yellow label: adhesion-associated pathway. For the top 50 gene sets see Supplementary Table S8.