Figure 3. Bowel evacuation of barium oatmeal paste after prokinetic agent in subjects with chronic SCI. Prior to intravenous placebo or drug administration, subjects had instillation of barium oatmeal paste in the rectum and descending colon. On separate days, subjects received in randomized-blinded design, 1 of 3 intravenous infusates: placebo (normal saline), neostigmine (2 mg), or neostigmine (2 mg) plus glycopyrrolate (0.4). Evacuation is represented from none (open section of the bar) to complete (darkest section of the bar). Neostigmine alone or neostigmine plus glycopyrrolate were similarly effective in inducing evacuation of the barium oatmeal paste from the bowel compared to negligible bowel evacuation after placebo administration. The figure was drawn from data presented in Korsten MA, et al. Am J Gastroenterol. 2005;100:1560-1565.