Figure 2.

(A) CD44⁺ cells induced by IL-6 differentiated into a variety of cell types after 10 days in standard culture conditions (right); few CD44⁺ cells were generated by culturing the isolated CD44⁻ cells in the standard culture conditions for the same period of time (left). (B-E) IL-6 induced CD44⁺ cells displayed significantly enhanced proliferation (B) and invasive (C) potential, increased resistance to radiation (D), and reduced cell death due to doxorubicin (E), compared with corresponding CD44⁻ cells.