Fig 2.
PA1 contributes to the pathogenesis of B. cereus G9241 anthrax-like disease in mice. (A) Survival of C57BL/6 mice (cohorts of 10 animals) following intraperitoneal injection of 1× 105 spores derived from B. cereus G9241 or its ΔpagA1 and ΔpagA2 mutant strains. (B) The bacterial loads in various organ tissues of dead or moribund C57BL/6 mice infected with either wild-type or ΔpagA1 or ΔpagA2 mutant B. cereus G9241 were quantified. Animals were necropsied, organs (spleen, kidney, liver, and lung) were removed, and tissue homogenates were spread on agar plates to enumerate colony formation. Data are representative of three independent experiments.