Table 1.
Gene expression profiling in tissues of C. rodentium-infected miR-155-deficient micea
| Day p.c. | Target ID | Symbol | Fold change | Adjusted P value | GO biological process |
|---|---|---|---|---|---|
| 4 | scl37307.8.1_29-S | Mmp3 | −3.79 | 0.00669 | Peptidoglycan metabolic process (GO:0000270), proteolysis (GO:0006508), collagen catabolic process (GO:0030574) |
| scl48501.9_645-S | Cd86 | −1.68 | 0.0127 | Defense response (GO:0006952) | |
| scl38155.8_378-S | Tnfaip3 | −1.99 | 0.0136 | Ubiquitin cycle (GO:0006512), apoptosis (GO:0006915) | |
| scl25940.13_350-S | Lat2 | −1.92 | 0.0144 | Immune response (GO:0006955), B cell activation (GO:0042113), mast cell degranulation (GO:0043303), B cell receptor signaling pathway (GO:0050853) | |
| scl0003597.1_94-S | Mmp3 | −2.45 | 0.0152 | Peptidoglycan metabolic process (GO:0000270), proteolysis (GO:0006508), collagen catabolic process (GO:0030574) | |
| scl37305.10.1_6-S | Mmp10 | −2.02 | 0.0187 | Peptidoglycan metabolic process (GO:0000270), proteolysis (GO:0006508), collagen catabolic process (GO:0030574) | |
| scl48625.8_280-S | Bcl6 | −1.93 | 0.0341 | Negative regulation of transcription from R-polymerase II promoter (GO:0000122), cell morphogenesis (GO:0000902), negative regulation of cell-matrix adhesion (GO:0001953), germinal center formation (GO:0002467), negative regulation of T-helper 2 type immunoresponse (GO:0002829), transcription (GO:0006350), regulation of transcription, D dependent (GO:0006355), Rho protein signal transduction (GO:0007266), spermatogenesis (GO:0007283), protein localization (GO:0008104), negative regulation of cell proliferation (GO:0008285), actin cytoskeleton organization and biogenesis (GO:0030036), B cell differentiation (GO:0030183), positive regulation of B cell proliferation (GO:0030890), regulation of Rho GTPase activity (GO:0032319), negative regulation of mast cell cytokine production (GO:0032764), negative regulation of Rho protein signal transduction (GO:0035024), T-helper 2 type immune response (GO:0042092), regulation of cell proliferation (GO:0042127), negative regulation of apoptosis (GO:0043056), regulation of memory T cell differentiation (GO:0043380), negative regulation of cell differentiation (GO:0045596), negative regulation of T-helper 2 cell differentiation (GO:0045629), negative regulation of isotype switching to IgE isotypes (GO:0048294), erythrocyte development (GO:0048821), regulation of inflammatory response (GO:0050727), positive regulation of cell motility (GO:0051272) | |
| scl30689.14.1_1-S | Cd19 | −1.98 | 0.0377 | ||
| scl0012514.2_91-S | Cd68 | −1.56 | 0.038 | ||
| scl41469.8_427-S | Tnfrsf13b | −2.18 | 0.0401 | B cell homeostasis (GO:0001782), immune response (GO:0006955), negative regulation of B cell proliferation (GO:0030889) | |
| scl38756.3.1_44-S | Vpreb3 | −2.27 | 0.0404 | ||
| scl21758.4.1_5-S | Cd2 | −1.67 | 0.0404 | Protein amino acid phosphorylation (GO:0006468), defense response (GO:0006952), cell adhesion (GO:0007155) | |
| scl44840.4_185-S | Cd83 | −2.26 | 0.0449 | ||
| scl44948.10_526-S | Irf4 | −1.6 | 0.0458 | Transcription (GO:0006350), regulation of transcription, D dependent (GO:0006355), myeloid dendritic cell differentiation (GO:0043011) | |
| 14 | scl53984.2_610-S | Cxcr3 | −1.52 | 0.0361 | Chemotaxis (GO:0006935), defense response (GO:0006952), signal transduction (GO:0007165), G-protein coupled receptor protein signaling pathway (GO:0007186) |
a
Immunomodulatory genes and genes involved in B cell differentiation and/or function (highlighted in gray) that were significantly downregulated in miR-155-deficient cecal patches on day 4 and day 14 p.c. compared with control mice.