Table 2.

Vaccination with CSP1 and poly(I·C)LC prevents 50% of mice from developing parasitemia after a low-dose sporozoite challenge^a

Immunization	No. of infected/no. of challenged mice	Prepatent period (days)	Protection (%)
20 μg CSP + poly(I·C)LC	5/10	5.8	50
Poly(I·C)LC	10/10	4.6	0
None (naive mice)	10/10	4.8	0

^aC57BL/6 mice (n = 10/group) were immunized three times, 3 weeks apart, with 20 μg CSP1 together with 50 μg poly(I·C)LC as the adjuvant. Mice that received poly(I·C)LC only or naive mice served as controls. Five weeks after the last immunization, mice were challenged i.v. with 1 × 10³ Pb-CS(Pf) sporozoites. Starting at day 4, daily blood smears were taken and observed under a microscope to look for the onset of parasitemia. Results are representative of two independent experiments.