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SagA is an active muramidase. (A) Protein alignment of SagA of Brucella abortus with enzymes from the bacteriophage T4, Zymomonas mobilis and Salmonella enterica. In gray are highlighted two conserved catalytic amino acids. (B) Enzymatic activity determined with different concentrations of recombinant SagA or the enzyme with the point mutations E17A and D26A. Activity determined at 10 min of reaction. (C) Activity of the site-directed mutants. *, P < 0.0001; **, P < 0.05.
