Table 3.
Osteogenic genes at least 3-fold upregulated or downregulated in osteoporotic bone tissue
| Gen symbol | ID gen(GeneBannk) | Function | Fold change |
|---|---|---|---|
| BGLAP |
NM_199173 |
Skeletal Development |
- 3.39 |
| BMP5 |
NM_ 001718 |
Skeletal Development |
- 3.87 |
| BMP6 |
NM_021073 |
Skeletal Development |
- 3.30 |
| CDH11 |
NM_001797 |
Bone Mineral Metabolism |
- 3.30 |
| COL14A1 |
NM_021110 |
Bone Mineral Metabolism |
- 9.54 |
| COMP |
NM_000095 |
Bone Mineral Metabolism |
- 4.63 |
| EGFR |
NM_005228 |
Cell growth and differentiation |
−5.28 |
| FGF1 |
NM_000800 |
Cell growth and differentiation |
3.3 |
| FGFR1 |
NM_015850 |
Cell growth and differentiation |
- 5.95 |
| FGFR2 |
NM_000141 |
Cell growth and differentiation |
- 5.63 |
| IGF1R |
NM_000875 |
Cell growth and differentiation |
- 8.96 |
| VEGFA |
NM_003376 |
Cell growth and differentiation |
3.00 |
| TGFBR1 |
NM_004612 |
Cell Proliferation |
- 6.31 |
| TGFRB2 |
NM_003242 |
Cell Proliferation |
- 7.04 |
| VCAM1 |
NM_001078 |
Cell adhesion Molecules |
- 8.36 |
| MMP2 |
NM_004530 |
Extracellular matrix Proteases |
- 4.36 |
| MMP8 |
NM_002424 |
Extracellular matrix Proteases |
5.06 |
| NFKB1 |
NM_003998 |
Transcription Factors and regulators |
- 3.06 |
| SMAD2 |
NM_005901 |
Transcription Factors and regulators |
- 3.42 |
| SMAD3 |
NM_005902 |
Transcription Factors and regulators |
- 5.25 |
| SOX9 |
NM_000346 |
Transcription Factors and regulators |
- 5.00 |
| RUNX-2 |
NM_004348 |
Transcription Factors and regulators |
- 2.94 |
| TNF | NM_000594 | Transcription Factors and regulators | - 9.18 |