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. 2012 Jul 12;33(11):2108–2118. doi: 10.1093/carcin/bgs242

Table V.

Meat mutagens and prostate cancer risk, by cancer stage

Meat mutagens (ng/1000 kcal/day) Controls Localized cases Advanced cases
n n ORa 95% CI ORb 95% CI n ORa 95% CI ORb 95% CI
PhIP
 Q1: ≥0 to <6.3 219 120 1.0Ref 1.0Ref 193 1.0Ref 1.0Ref
 Q2: ≥6.3 to <21.5 217 120 1.0 0.7–1.4 0.9 0.7–1.3 208 1.1 0.8–1.4 1.0 0.8–1.4
 Q3: ≥21.5 to <47.0 219 135 1.1 0.8–1.6 1.1 0.8–1.6 257 1.3 1.0–1.7 1.3 1.0–1.7
 Q4: ≥47.0 to <105.4 219 166 1.3 1.0–1.8 1.3 0.9–1.8 231 1.2 0.9–1.5 1.1 0.8–1.5
 Q5: ≥105.4 219 174 1.2 0.9–1.7 1.2 0.9–1.7 250 1.3 1.0–1.7 1.2 0.9–1.6
 P trend 0.144 0.156 0.158 0.245
MelQx
 Q1: ≥0 to <4.0 219 134 1.0Ref 1.0Ref 217 1.0Ref 1.0Ref
 Q2: ≥4.0 to <9.7 217 94 0.6 0.4–0.9 0.6 0.4–0.9 189 0.9 0.6–1.1 0.8 0.6–1.1
 Q3: ≥9.7 to <17.3 219 133 0.9 0.6–1.2 0.9 0.6–1.2 231 1.0 0.8–1.3 1.0 0.7–1.3
 Q4: ≥17.3 to <31.9 219 148 0.9 0.6–1.2 0.9 0.6–1.2 252 1.1 0.9–1.5 1.1 0.8–1.4
 Q5: ≥31.9 219 206 1.0 0.7–1.4 1.0 0.7–1.4 250 1.1 0.8–1.4 1.0 0.8–1.4
 P trend 0.279 0.308 0.233 0.417
DiMelQx
 Q1: ≥0 to <0.1 247 148 1.0Ref 1.0Ref 247 1.0Ref 1.0Ref
 Q2: ≥0.1 to <0.4 190 99 0.8 0.6–1.2 0.8 0.6–1.1 162 0.8 0.6–1.1 0.8 0.6–1.1
 Q3: ≥0.4 to <1.0 219 126 0.9 0.6–1.2 0.9 0.6–1.2 246 1.1 0.9–1.5 1.1 0.8–1.4
 Q4: ≥1.0 to <2.2 218 157 1.0 0.7–1.4 1.0 0.8–1.4 234 1.0 0.8–1.4 1.0 0.8–1.3
 Q5: ≥2.2 219 185 1.0 0.7–1.3 1.0 0.7–1.3 250 1.1 0.8–1.4 1.0 0.8–1.3
 P trend 0.586 0.657 0.411 0.680
BAP
 Q1: ≥0 to <0.6 219 138 1.0Ref 1.0Ref 234 1.0Ref 1.0Ref
 Q2: ≥0.6 to <2.4 219 160 0.9 0.7–1.3 0.9 0.6–1.2 249 1.0 0.8–1.3 1.0 0.7–1.3
 Q3: ≥2.4 to <10.0 219 168 1.0 0.8–1.4 1.0 0.7–1.4 231 1.0 0.7–1.3 0.9 0.7–1.2
 Q4: ≥10.0 to <27.1 218 112 0.8 0.6–1.2 0.8 0.6–1.2 209 0.9 0.7–1.2 0.9 0.7–1.1
 Q5: ≥27.1 218 137 0.9 0.7–1.3 0.9 0.6–1.3 216 0.9 0.7–1.2 0.9 0.7–1.1
 P trend 0.757 0.660 0.544 0.396
Mutagenic activity (number of revertant colonies)
 Q1: ≥0 to <629 218 113 1.0Ref 1.0Ref 197 1.0Ref 1.0Ref
 Q2: ≥629 to <1433 219 97 0.8 0.5–1.1 0.7 0.5–1.1 201 1.0 0.8–1.3 0.9 0.7–1.3
 Q3: ≥1433 to <2626 219 149 1.2 0.8–1.7 1.2 0.8–1.7 257 1.3 1.0–1.7 1.3 1.0–1.7
 Q4: ≥2626 to <4950 218 176 1.4 1.0–1.9 1.4 1.0–2.0 231 1.2 0.9–1.6 1.1 0.8–1.5
 Q5: ≥4950 219 180 1.1 0.8–1.5 1.1 0.8–1.5 253 1.2 0.9–1.6 1.1 0.9–1.5
 P trend 0.286 0.341 0.208 0.329
Mutagenic activity (number of predicted revertant colonies)
 Q1: ≥0 to <735 219 129 1.0Ref 1.0Ref 222 1.0Ref 1.0Ref
 Q2: ≥735 to <1620 218 107 0.8 0.5–1.1 0.8 0.5–1.1 206 0.9 0.7–1.2 0.9 0.7–1.1
 Q3: ≥1620 to <2665 218 133 0.9 0.6–1.2 0.9 0.6–1.2 234 1.0 0.8–1.3 1.0 0.7–1.3
 Q4: ≥2665 to <4409 219 138 0.8 0.6–1.2 0.8 0.6–1.2 226 1.0 0.8–1.3 0.9 0.7–1.2
 Q5: ≥4409 219 208 1.0 0.7–1.4 1.0 0.7–1.4 251 1.1 0.8–1.4 1.0 0.8–1.3
 P trend 0.478 0.480 0.417 0.664

aAdjusted for age (years), BMI (<25, 25–29, ≥30), total calorie intake (kcal/day) and family history of PCA (yes/no).

bAdjusted for age (years), BMI (<25, 25–29, ≥30), total calorie intake(kcal/day), family history of PCA (yes/ no), total fat intake (g/day), alcohol consumption (g/day), cigarette smoking (pack-years), total fruit consumption (g/day), total vegetable consumption (g/ day).