Table VI.

Interaction of meat derived mutagens/ mutagenic activity and PTGS2 SNP (rs20417) in the risk of advanced prostate cancer

Exposure (ng/1000 kcal/ day)	GG (Co/Ca)	G/C (Co/Ca)	C/C (Co/Ca)	G/G genotype		G/C genotype		C/C genotype
PGTS2 −765G>C	G/G	G/C	C/C	ORa,b	95% CI	ORa,b	95% CI	ORa,b	95% CI
Marginal effect of rs20417	481/595	237/304	38/36	1.0Ref		1.0	0.9–1.2	1.1	0.7–1.5
Mutagenic activity (number of revertant colonies)
≥0 to <1186	164/163	70/98	9/10	1.0Ref		1.4	1.0–1.9	1.9	1.0–3.6
≥1186 to <3260	170/206	74/102	10/13	1.3	0.9–1.7	1.5	1.1–2.1	1.8	1.0–3.2
≥3260	147/226	93/104	19/13	1.6	1.2–2.2	1.2	0.8–1.6	0.9	0.5–1.5
P trend					0.004		0.246		0.016
P Heterogeneity of trend	0.002
P LR test for interaction	0.008
Mutagenic activity (number of predicted revertant colonies)
≥0 to <1305	157/179	77/96	5/8	1.0Ref		1.2	0.8–1.6	1.3	0.7–2.6
≥1305 to <3210	177/198	66/112	13/17	1.0	0.7–1.4	1.4	1.0–2.0	2.0	1.1–3.4
≥3210	147/218	94/96	20/11	1.3	1.0–1.8	0.9	0.7–1.3	0.6	0.4–1.1
P trend					0.059		0.086		0.011
P Heterogeneity of trend	0.004
P LR test for interaction	0.003
MeIQx
≥0 to <7.8	153/166	73/93	8/8	1.0Ref		1.1	0.8–1.6	1.3	0.7–2.4
≥7.8 to <21.1	179/198	66/101	12/17	1.0	0.7–1.4	1.4	1.0–1.9	1.9	1.1–3.3
≥21.1	149/231	98/110	18/11	1.4	1.0–1.9	1.0	0.7–1.4	0.7	0.4–1.3
P trend					0.028		0.263		0.037
P Heterogeneity of trend	0.010
P LR test for interaction	0.007

^aAdjusted for age (years), BMI (<25, 25–29, ≥30), total calorie intake (kcal/day) and family history of PCA (yes/ no).

^bOdds ratios are from models with genotype coded as log-additive (i.e., number of C alleles, treated as continuous).