Fig. 3.

Histology of breakthrough tumors and non-involved mammary tissues. Breakthrough tumors arising in i.duc void polymer (A) and i.duc NanoCurc (B) are tubuloalveolar adenocarcinomas. NanoCurc breakthrough tumors also harbor some areas that are more solid or cribriform with less stroma. Comparable tumor histologies in i.duc free curcumin and oral free curcumin are not shown.

Areas of normal mammary gland from all four groups – (C) = i.duc free curcumin, (D) = i.duc NanoCurc, (E) = oral free curcumin, and (F) = i.duc void polymer – displayed minimal periductal infiltrates including mononuclear cells and rare neutrophils. The histology was similar in all four groups at the cellular level in non-tumor areas of the mammary gland.