Table III.

Immunohistochemical assessments of inflammation, proliferation and apoptosis in mammary tissue

Comparison	P value by likelihood ratio test
	pp65	Ki67	CCND1	pH3	Caspase 3
i.duc void polymer versus i.duc NanoCurc	0.0001	0.003	0.407	<0.0001	0.880
i.duc void polymer versus i.duc free curcumin	0.067	0.003	0.764	0.086	<0.0001
i.duc void polymer versus oral free curcumin	0.345	0.894	0.008	0.007	<0.0001
i.duc NanoCurc versus i.duc free curcumin	0.051	>0.999	0.302	0.093	0.0004
i.duc NanoCurc versus oral free curcumin	0.002	0.015	0.079	<0.0001	0.004
i.duc free curcumin versus oral free curcumin	0.339	0.015	0.005	0.002	0.127

Nuclear localization of pp65 (phospho p65), the principal subunit protein of NFκB and a marker of inflammation, and proliferation markers: Cyclin D1 (CCND1), phospho-histone H3 (pH3) and Ki67 was significantly decreased, whereas cleaved caspase 3, a marker of apoptosis, was significantly increased in several treatment comparisons.

To account for multiple testing, a significant difference is considered at P < 0.0083 based on Bonferroni adjustment.