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Time course of cannabinoid plasma concentrations over six days of around-the-clock oral THC administration: THC (A); 11-OH-THC (B). Peripheral venous blood was collected at indicated time points, and plasma was separated within 2 h, stored at 4°C (with one exception), and analyzed by GC–MS within 10 ± 5 days for unconjugated THC and 11-OH-THC. Vertical bars indicate SEM.
